The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 26, 2014

Filed:

Mar. 23, 2011
Applicants:

Jorge Alsina-fernandez, Indianapolis, IN (US);

Krister Bengt Bokvist, Carmel, IN (US);

Lili Guo, Carmel, IN (US);

John Philip Mayer, Indianapolis, IN (US);

Inventors:

Jorge Alsina-Fernandez, Indianapolis, IN (US);

Krister Bengt Bokvist, Carmel, IN (US);

Lili Guo, Carmel, IN (US);

John Philip Mayer, Indianapolis, IN (US);

Assignee:

Eli Lilly and Company, Indianapolis, IN (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/16 (2006.01); A61P 3/10 (2006.01); C07K 14/00 (2006.01); C07K 14/595 (2006.01); C07K 14/605 (2006.01); C07K 14/72 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/605 (2013.01); C07K 14/723 (2013.01); A61K 38/00 (2013.01);
Abstract

The present invention is in the field of treatment of diabetes and relates to peptides that exhibit activity for both glucose-dependent insulinotropic peptide receptor (GIP-R) and glucagon-like peptide-1 receptor (GLP-1-R) and are selective over glucagon receptor (Gluc-R). Specifically provided are GIP analogs with amino acid substitutions introduced to modulate activity for both GIP-R and GLP-1-R and maintain selectivity over Gluc-R.


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