The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2014
Filed:
Dec. 16, 2010
Christoph Kalthoff, Frederikssund, DK;
Jesper Lau, Farum, DK;
Jane Spetzler, Broenshoej, DK;
Patrick William Garibay, Holte, DK;
Jacob Kofoed, Vaerloese, DK;
Lars Linderoth, Alleroed, DK;
Christoph Kalthoff, Frederikssund, DK;
Jesper Lau, Farum, DK;
Jane Spetzler, Broenshoej, DK;
Patrick William Garibay, Holte, DK;
Jacob Kofoed, Vaerloese, DK;
Lars Linderoth, Alleroed, DK;
Novo Nordisk A/S, Bagsvaerd, DK;
Abstract
The invention relates to a GLP-1 analog which comprises a histidine (H) residue at a position corresponding to position 31 of GLP-1(7-37) (SEQ ID NO: 1), a glutamine (Q) residue at a position corresponding to position 34 of GLP-1 (7-37) (SEQ ID NO: 1), and a maximum of ten amino acid modifications as compared to GLP-1 (7-37) (SEQ ID NO: 1); wherein the H residue is designated H, and the Q residue is designated Q; or a pharmaceutically acceptable salt, amide, or ester thereof. The invention also relates to derivatives thereof, as well as the pharmaceutical use of these analogs and derivatives, for example in the treatment and/or prevention of all forms of diabetes and related diseases. The invention furthermore relates to corresponding novel side chain intermediates. The derivatives are suitable for oral administration.