The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2014
Filed:
Oct. 23, 2013
Applicant:
University of Washington, Seattle, WA (US);
Inventors:
Michael A. Laflamme, Seattle, WA (US);
Wei-Zhong Zhu, Seattle, WA (US);
Assignee:
University of Washington, Seattle, WA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/071 (2010.01); A61K 35/12 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0657 (2013.01); C12N 2501/155 (2013.01); C12N 2510/00 (2013.01); C12N 2502/13 (2013.01); C12N 2501/11 (2013.01); A61K 35/12 (2013.01); C12N 2506/02 (2013.01); C12N 2501/16 (2013.01); C12N 2501/13 (2013.01); C12N 2533/90 (2013.01); C12N 2501/115 (2013.01);
Abstract
The present invention is directed to methods of producing cardiomyocytes having a nodal/pacemaker phenotype and cardiomyocytes having an atrial/ventricular phenotype. Isolated populations of nodal/pacemaker and atrial/ventricular cardiomyocytes are also disclosed. Methods of treating a subject having cardiac arrhythmia and a subject in need of cardiac tissue repair using the isolated populations of nodal/pacemaker cardiomyocytes and atrial/ventricular cardiomyocytes, receptively, are also disclosed.