The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2014
Filed:
Jul. 10, 2006
Raphael C. Lee, Chicago, IL (US);
Annie Kuo, Salt Lake City, UT (US);
Hanne Gissel Hyldkrog, Trige, DK;
Florin Despa, North Riverside, IL (US);
Devkumar Mustafi, Chicago, IL (US);
Raphael C. Lee, Chicago, IL (US);
Annie Kuo, Salt Lake City, UT (US);
Hanne Gissel Hyldkrog, Trige, DK;
Florin Despa, North Riverside, IL (US);
Devkumar Mustafi, Chicago, IL (US);
University of Chicago, Chicago, IL (US);
Abstract
Compounds and methods for refolding of proteins in an aqueous solution. In particular, biocompatible multiblock copolymer surfactants such as poloxamers, meroxapols, poloxamines, or polyols are used to catalyze proper refolding without changing the protein composition, and restore the protein to its native conformation and native biological function. The methods can be practiced both in vivo and in vitro. The biocompatible multiblock copolymer surfactants can be used for renaturation of recombinantly expressed proteins, and for renaturation of proteins that are unfolded due to heat, irradiation, mechanical shearing, electrical shock, frostbite, chemical stress, and other abiotic or biotic stresses.