The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2014
Filed:
Mar. 31, 2006
Edina Garaczi, Lakewood, OH (US);
Hideaki Sugiyama, Yamanashi, JP;
Rolland Gyulai, Szeged, HU;
Kevin D. Cooper, Moreland Hills, OH (US);
Thomas S. Mccormick, Orange Village, OH (US);
Edina Garaczi, Lakewood, OH (US);
Hideaki Sugiyama, Yamanashi, JP;
Rolland Gyulai, Szeged, HU;
Kevin D. Cooper, Moreland Hills, OH (US);
Thomas S. McCormick, Orange Village, OH (US);
Case Western Reserve University, Cleveland, OH (US);
Abstract
An affinity ligand is reactive to the GARP protein may be capable of binding to an extracellular domain of GARP protein expressed on regulatory T (Treg) cells. The affinity ligand may be an antibody and may be used to identify Treg cells. A method comprises providing a blood sample from a subject and determining the amount of Treg cells in that sample. A composition containing Treg cells may be administered to an individual to suppress effector T cell activity in the individual. A composition containing an affinity ligand capable of binding to a GARP domain may be administered to an individual to suppress Treg cell activity and increase effector T cell activity in the individual. A kit for detecting Treg cells may include an affinity ligand reactive with mammalian GARP protein.