The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2014
Filed:
Sep. 14, 2006
Applicants:
Gunther Hartmann, Bonn, DE;
Veit Hornung, Pullach, DE;
Inventors:
Gunther Hartmann, Bonn, DE;
Veit Hornung, Pullach, DE;
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); A61K 39/39 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); A61K 38/20 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39 (2013.01); A61K 38/208 (2013.01);
Abstract
The present invention provides 4-nucleotide (4mer) RNA motifs that confer immunostimulatory activity, in particular, IL-12-inducing activity to a single-stranded RNA oligonucleotide. The present invention also provides single-stranded RNA oligonucleotides, including antisense RNA, with high or low immunostimulatory activity. The present invention further provides the use of the RNA oligonucleotides of the invention for therapeutic purposes.