The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 26, 2014
Filed:
May. 24, 2007
Erik Robbert Vossenaar, De Meern, NL;
Marc Wilhelmus Gijsbert Ponjee, Tilburg, NL;
Hendrik Roelof Stapert, Eindhoven, NL;
Mark Thomas Johnson, Velhoven, NL;
Erik Robbert Vossenaar, De Meern, NL;
Marc Wilhelmus Gijsbert Ponjee, Tilburg, NL;
Hendrik Roelof Stapert, Eindhoven, NL;
Mark Thomas Johnson, Velhoven, NL;
Koninklijke Philips N.V., Eindhoven, NL;
Abstract
The invention relates to a microelectronic sensor device and a method for the investigation of biological target substances (), for example oligonucleotides like DNA fragments. In one embodiment, the device comprises a reaction surface (RS) to which target specific reactants () are attached and which lies between a sample chamber (SC) and an array of selectively controllable heating elements (HE). The temperature profile in the sample chamber (SC) can be controlled as desired to provide for example conditions for a PCR and/or for a controlled melting of hybridizations. The reactant () and/or the target substance () comprises a label () with an observable property, like fluorescence, that changes if the target substance () is bound to the reactant (), said property being detected by an array of sensor elements, for example photosensors (SE). The fluorescence of the label () may preferably be transferred by FRET to a different fluorescent label () or quenched if the target substance () is bound.