The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 2014
Filed:
Jul. 15, 2011
James Alan Kerschen, Somerset, NJ (US);
Alexander James Bridges, Saline, MI (US);
Sean Mark Dalziel, San Francisco, CA (US);
Olivier Dapremont, Cameron Park, CA (US);
Hyunjung Kim, Collegeville, PA (US);
Andrew S. Thompson, Mountainside, NJ (US);
James Robert Zeller, Scottsdale, AZ (US);
James Alan Kerschen, Somerset, NJ (US);
Alexander James Bridges, Saline, MI (US);
Sean Mark Dalziel, San Francisco, CA (US);
Olivier Dapremont, Cameron Park, CA (US);
Hyunjung Kim, Collegeville, PA (US);
Andrew S. Thompson, Mountainside, NJ (US);
James Robert Zeller, Scottsdale, AZ (US);
ONYX Pharmaceuticals, Inc., San Francisco, CA (US);
Abstract
A method of producing 6-amino-cyclopenta[g]quinazolines, in enantiomerically enriched form, is provided. In particular, the method may be applicable to the synthesis of N—{N-{4-[N-((6S)-2 -hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclo-penta[g]quinazolin-6-yl)-N-(prop-2 -ynyl)amino]benzoyl}-L-γ-glutamyl}-D-glutamic acid (ONX-0801).