The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 19, 2014

Filed:

Jan. 04, 2013
Applicant:

Ardelyx, Inc., Fremont, CA (US);

Inventors:

Jason G. Lewis, Castro Valley, CA (US);

Jeffrey W. Jacobs, San Mateo, CA (US);

Nicholas Reich, Berkeley, CA (US);

Michael R. Leadbetter, San Leandro, CA (US);

Noah Bell, Berkeley, CA (US);

Han-Ting Chang, Livermore, CA (US);

Tao Chen, Palo Alto, CA (US);

Marc Navre, Belmont, CA (US);

Dominique Charmot, Campbell, CA (US);

Christopher Carreras, Belmont, CA (US);

Eric Labonte, Redwood City, CA (US);

Assignee:

Ardelyx, Inc., Fremont, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 241/20 (2006.01); C07D 239/28 (2006.01); C07D 403/12 (2006.01); A61K 31/506 (2006.01); A61K 31/505 (2006.01); A61K 31/4965 (2006.01); A61K 31/497 (2006.01);
U.S. Cl.
CPC ...
Abstract

Compounds having activity as phosphate transport inhibitors, more specifically, inhibitors of intestinal apical membrane Na/phosphate co-transport, are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein X, Y and A are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.


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