The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 2014
Filed:
Oct. 25, 2010
Jinhua Zhao, Shenzhen, CN;
Hui Kang, Shenzhen, CN;
Mingyi Wu, Shenzhen, CN;
Weizhen Zeng, Shenzhen, CN;
Zi LI, Shenzhen, CN;
Yuan Gao, Shenzhen, CN;
Jing Cui, Shenzhen, CN;
Zhiguo Wang, Shenzhen, CN;
Hanlin Feng, Shenzhen, CN;
Lin Yu, Shenzhen, CN;
Jinhua Zhao, Shenzhen, CN;
Hui Kang, Shenzhen, CN;
Mingyi Wu, Shenzhen, CN;
Weizhen Zeng, Shenzhen, CN;
Zi Li, Shenzhen, CN;
Yuan Gao, Shenzhen, CN;
Jing Cui, Shenzhen, CN;
Zhiguo Wang, Shenzhen, CN;
Hanlin Feng, Shenzhen, CN;
Lin Yu, Shenzhen, CN;
Shenzhen Neptunus Pharmaceutical Co., Ltd., Guangdong, CN;
Abstract
Disclosed is a depolymerized glycosaminoglycan from(dTHG), weight average molecular weight of which is about 8000˜20000 Da, and monosaccharide components of which are acetylgalactosamine (GalNAc), glucuronic acid (GlcUA), fucose (Fuc) or their sulfates (expressed as —OSO), in which molar ratio of GalNAc:GlcUA:Fuc:—OSOis about 1:(1±0.3):(1±0.3):(3.5±0.5). Said dTHG is a potent endogenous inhibitor of factor X, which has good anticoagulant and antithrombotic activity, and can be used for the prevention and/or treatment of thrombotic diseases. Also provided is a method for preparing said dTHG, which comprises steps of 1) extracting and obtaining fucosylated glycosaminoglycan (THG) from the body wall of; 2) depolymerizing THG to obtain dTHG by method of peroxide depolymerization or method of peroxide depolymerization catalyzed by catalyst of the fourth period transition metal ions; 3) removing impurities with lower and/or higher molecular weight in dTHG.