The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 2014
Filed:
Jan. 07, 2011
Kyung Chan Park, Daejeon, KR;
Young IL Yeom, Daejeon, KR;
Tae Woo Kim, Daejeon, KR;
Zee-yong Park, Daejeon, KR;
Yun Kyung Kang, Daejeon, KR;
Suk-jin Yang, Daejeon, KR;
Byung-jung Choi, Daejeon, KR;
Dong Chul Lee, Daejeon, KR;
Hyun Ahm Shon, Daejeon, KR;
Hyang-sook Yoo, Daejeon, KR;
Kyung Chan Park, Daejeon, KR;
Young Il Yeom, Daejeon, KR;
Tae Woo Kim, Daejeon, KR;
Zee-Yong Park, Daejeon, KR;
Yun Kyung Kang, Daejeon, KR;
Suk-Jin Yang, Daejeon, KR;
Byung-Jung Choi, Daejeon, KR;
Dong Chul Lee, Daejeon, KR;
Hyun Ahm Shon, Daejeon, KR;
Hyang-Sook Yoo, Daejeon, KR;
Korea Research Institute of Bioscience and Biotechnology, Daejeon, KR;
Abstract
The present invention relates to a composition comprising an inhibitor of the expression or activity of SH3 domain containing ring finger 2 (SH3RF2) for preventing or treating cancers. More specifically, since the SH3RF2 protein, of which the expression level increases in various cancer tissues, binds to PAK4, which is a cancer-associated gene, to regulate an apoptosis inhibitory function of the PAK4 protein by ubiquitination activity of SH3RF2 RING domain, cancer cells, in which the expression of SH3RF2 is inhibited, sensitively respond to the induction of apoptosis to promote apoptosis and reduce in vivo tumorigenicity, such that the inhibitor of the expression or activity of SHRF2 can be useful as a composition for preventing or treating cancers.