The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 2014
Filed:
Jul. 30, 2008
Yasuhiro Kajihara, Tokushima, JP;
Izumi Sakamoto, Tokushima, JP;
Yuri Nambu, Tokushima, JP;
Kazuhiro Fukae, Tokushima, JP;
Hiroaki Asai, Tokushima, JP;
Yasuhiro Kajihara, Tokushima, JP;
Izumi Sakamoto, Tokushima, JP;
Yuri Nambu, Tokushima, JP;
Kazuhiro Fukae, Tokushima, JP;
Hiroaki Asai, Tokushima, JP;
Glytech, Inc., Kyoto, JP;
Abstract
The present invention provides a method for producing a peptide, characterized in that it comprises converting an —SH group of a peptide comprising an amino acid residue having the —SH group to an —OH group, wherein said method comprises the following steps (a) to (c): (a) allowing an —SH group in a peptide to react with a methylating agent to convert the —SH group to an -SMe group; (b) allowing the -SMe group obtained in the step (a) to react with a cyanizing agent to produce a reaction intermediate; and (c) converting the reaction intermediate obtained in the step (b) to a peptide comprising an amino acid residue having an —OH group under more basic conditions than the conditions in the step (b).