The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 2014
Filed:
Aug. 20, 2007
Aya Jakobovits, Menlo Park, CA (US);
Raju Kucherlapati, Darien, CT (US);
Susan Klapholz, Stanford, CA (US);
Michael J Mendez, El Granada, CA (US);
Larry Green, San Francisco, CA (US);
Aya Jakobovits, Menlo Park, CA (US);
Raju Kucherlapati, Darien, CT (US);
Susan Klapholz, Stanford, CA (US);
Michael J Mendez, El Granada, CA (US);
Larry Green, San Francisco, CA (US);
Amgen Fremont Inc., South San Francisco, CA (US);
Abstract
The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (Vand Vκ) gene regions. Advantageously, the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high affinity antibodies.