The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 19, 2014
Filed:
May. 25, 2009
Bennard Van Ravenzwaay, Altrip, DE;
Werner Mellert, Hassloch, DE;
Georgia Coelho Palermo Cunha, Sao Paulo, BR;
Eric Fabian, Ludwigshafen, DE;
Volker Strauss, Bad Duerkheim, DE;
Hennicke Kamp, Bischheim, DE;
Tilmann B. Walk, Kleinmachnow, DE;
Ralf Looser, Berlin, DE;
Michael Manfred Herold, Berlin, DE;
Jan C. Wiemer, Berlin, DE;
Alexandre Prokoudine, Berlin, DE;
Edgar Leibold, Carlsberg, DE;
Bennard van Ravenzwaay, Altrip, DE;
Werner Mellert, Hassloch, DE;
Georgia Coelho Palermo Cunha, Sao Paulo, BR;
Eric Fabian, Ludwigshafen, DE;
Volker Strauss, Bad Duerkheim, DE;
Hennicke Kamp, Bischheim, DE;
Tilmann B. Walk, Kleinmachnow, DE;
Ralf Looser, Berlin, DE;
Michael Manfred Herold, Berlin, DE;
Jan C. Wiemer, Berlin, DE;
Alexandre Prokoudine, Berlin, DE;
Edgar Leibold, Carlsberg, DE;
BASF SE, Ludwigshafen, DE;
Abstract
The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing the pro-pathological effect of compounds which are inducing liver enzymes. It also relates to a method of determining whether a compound is capable of exhibiting pro-pathological effects on the liver by enzyme induction in a subject and to a method of identifying a drug for treating the pro-pathological effect of liver enzyme induction. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five analytes, a data storage medium comprising said data collection, and a system and a device for diagnosing the pro-pathological effect of liver enzyme induction. Finally, the present invention pertains to the use of a group of analytes or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing the pro-pathological effect of liver enzyme induction in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver enzyme induction markers are mainly selected from free fatty acids, but also include various phosphatidylcholines, galactose, 3- and 5-Methoxysphingosine, Cholesterol, Threonic acid, 1,2-Dioleoyl-sn-glycero-3-phosphatidyl-L-serine, Glycerol, Glycerophosphate, Dodecanol, myo-Inositol-2-monophosphate.