The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2014
Filed:
May. 18, 2011
Brian W. Budzik, Perkiomenville, PA (US);
Steven L. Colletti, Princeton Junction, NJ (US);
Darla Danile Seifried, Lansdale, PA (US);
Matthew G. Stanton, Marlton, NJ (US);
LU Tian, Jamison, PA (US);
Brian W. Budzik, Perkiomenville, PA (US);
Steven L. Colletti, Princeton Junction, NJ (US);
Darla Danile Seifried, Lansdale, PA (US);
Matthew G. Stanton, Marlton, NJ (US);
Lu Tian, Jamison, PA (US);
Sirna Therapeutics, Inc., Cambridge, MA (US);
Abstract
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that is more efficacious than traditional cationic lipids. The present invention employs amino alcohols to enhance the efficiency of in vivo delivery of siRNA.