The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2014
Filed:
Sep. 04, 2008
Wenbing Yao, Jiangsu, CN;
Hong Tian, Jiangsu, CN;
Xiangyang Xu, Jiangsu, CN;
Hairui LI, Jiangsu, CN;
Yue Dong, Jiangsu, CN;
Xiangdong Gao, Jiangsu, CN;
Wenbing Yao, Jiangsu, CN;
Hong Tian, Jiangsu, CN;
Xiangyang Xu, Jiangsu, CN;
Hairui Li, Jiangsu, CN;
Yue Dong, Jiangsu, CN;
Xiangdong Gao, Jiangsu, CN;
Jiangsu Simcere Pharmaceutical R&D Co., Ltd., Jiangsu, CN;
Shandong Xiansheng Maidejin Biological Pharmaceutical Co., Ltd., Shandong, CN;
Abstract
Provided is a kind of modified recombinant human endostatin that has the structure of CHO—(CHCHO)—CHCHCH—NH-Endostar, wherein the average molecular weight of CHO—(CHCHO)—CHCHCH— is 20-40 kD. The modified recombinant human endostatin enhances the stability in vivo, improves blood drug concentration, prolongs half-life, markedly increases the activity of inhibiting the endothelial cells proliferation, thus reduces drug dosage and decreases administration frequency. Its application for preparing anti-tumor pharmaceutical compositions is also provided.