The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2014
Filed:
Mar. 15, 2013
David B Rozema, Middleton, WI (US);
David L Lewis, Madison, WI (US);
Darren H Wakefield, Fitchburg, WI (US);
Eric a Kitas, Aesch BL, CH;
Philipp Hadwiger, Kulmbach, DE;
Jon a Wolff, Madison, WI (US);
Ingo Roehl, Memmelsdorf, DE;
Peter Mohr, Basel, CH;
Torsten Hoffmann, Weil am Rhein, DE;
Kerstin Jahn-hofmann, Neu-Isenburg, DE;
Hans Martin Mueller, Munich, DE;
Guenther Ott, Bayreuth, DE;
Andrei V Blokhin, Fitchburg, WI (US);
Jeffrey C Carlson, Madison, WI (US);
Jonathan D Benson, Stoughton, WI (US);
David B Rozema, Middleton, WI (US);
David L Lewis, Madison, WI (US);
Darren H Wakefield, Fitchburg, WI (US);
Eric A Kitas, Aesch BL, CH;
Philipp Hadwiger, Kulmbach, DE;
Jon A Wolff, Madison, WI (US);
Ingo Roehl, Memmelsdorf, DE;
Peter Mohr, Basel, CH;
Torsten Hoffmann, Weil am Rhein, DE;
Kerstin Jahn-Hofmann, Neu-Isenburg, DE;
Hans Martin Mueller, Munich, DE;
Guenther Ott, Bayreuth, DE;
Andrei V Blokhin, Fitchburg, WI (US);
Jeffrey C Carlson, Madison, WI (US);
Jonathan D Benson, Stoughton, WI (US);
Arrowhead Madison Inc., Madison, WI (US);
Abstract
The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalently linked to an RNAi polynucleotide or co-administered with a targeted RNAi polynucleotide-targeting molecule conjugate.