The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2014
Filed:
Apr. 22, 2013
Acylamino-substituted fused cyclopentanecarboxylic acid derivatives and their use as pharmaceuticals
Sanofi, Paris, FR;
Matthias Schaefer, Frankfurt am Main, DE;
Josef Pernerstorfer, Frankfurt am Main, DE;
Dieter Kadereit, Frankfurt am Main, DE;
Hartmut Strobel, Frankfurt am Main, DE;
Werngard Czechtizky, Frankfurt am Main, DE;
L. Charlie Chen, Tucson, AZ (US);
Alena Safarova, Tucson, AZ (US);
Aleksandra Weichsel, Tucson, AZ (US);
Marcel Patek, Tucson, AZ (US);
Sanofi, Paris, FR;
Abstract
The present invention relates to compounds of the formula I, wherein A, Y, Z, Rto R, Rto Rand Rhave the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also termed as LPAreceptor, and are useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.