The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 12, 2014

Filed:

Jun. 14, 2010
Applicants:

Andreas Goutopoulos, Boston, MA (US);

Benny C. Askew, Jr., Marshfield, MA (US);

Nhut Kiet Diep, Hauppauge, NY (US);

Srinivasa R. Karra, Pembroke, MA (US);

Matthias Schwarz, Gland, CH;

Henry Yu, Wellesley, MA (US);

Inventors:

Andreas Goutopoulos, Boston, MA (US);

Benny C. Askew, Jr., Marshfield, MA (US);

Nhut Kiet Diep, Hauppauge, NY (US);

Srinivasa R. Karra, Pembroke, MA (US);

Matthias Schwarz, Gland, CH;

Henry Yu, Wellesley, MA (US);

Assignee:

Merck Serono S.A., Coinsins, Vaud, CH;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/465 (2006.01); A61K 31/4412 (2006.01); A61K 31/44 (2006.01); C07D 213/81 (2006.01); C07D 213/80 (2006.01); C07D 213/82 (2006.01); C07D 405/12 (2006.01); C07D 213/84 (2006.01); C07D 237/24 (2006.01); C07D 213/79 (2006.01); A61P 35/00 (2006.01); A61P 29/00 (2006.01);
U.S. Cl.
CPC ...
C07D 213/84 (2013.01); C07D 213/81 (2013.01); C07D 213/80 (2013.01); C07D 213/82 (2013.01); C07D 405/12 (2013.01); C07D 237/24 (2013.01); C07D 213/79 (2013.01);
Abstract

The invention provides novel arylamino N-heteroaryl MEK inhibitors of Formula (I): Such compounds are MEK inhibitors that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation. Also disclosed is the treatment of a hyperproliferative disease in mammals, and pharmaceutical compositions containing such compounds.


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