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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8802675 B1

PDFFull Text
Date of Patent:
Aug. 12, 2014

Filed:

Jan. 31, 2010

Neuroprotective multifunctional compounds and pharmaceutical compositions comprising them

Applicants:

Moussa B. H. Youdim, Haifa, IL;

Mati Fridkin, Rehovot, IL;

Hailin Zheng, Nanning, CN;

Inventors:

Moussa B. H. Youdim, Haifa, IL;

Mati Fridkin, Rehovot, IL;

Hailin Zheng, Nanning, CN;

Assignees:

Technion Research and Development Foundation Ltd, Haifa, IL;

Yeda Research and Development Company Ltd., Rehovot, IL;

Attorney:

Browdy and Neimark, PLLC

Primary Examiner:

Sarah Pihonak

Int. Cl.
CPC ...
A01N 43/64 (2006.01); A61K 31/53 (2006.01); A01N 43/58 (2006.01); A01N 43/60 (2006.01); A61K 31/50 (2006.01); A61K 31/495 (2006.01); A61K 31/497 (2006.01); A01N 43/54 (2006.01); A61K 31/517 (2006.01); A01N 43/42 (2006.01); A61K 31/47 (2006.01); A01N 43/40 (2006.01); A61K 31/445 (2006.01); A01N 47/10 (2006.01); A61K 31/27 (2006.01); A01N 33/02 (2006.01); A61K 31/135 (2006.01); A61K 31/13 (2006.01); C07D 253/08 (2006.01); C07D 487/00 (2006.01); C07D 239/72 (2006.01); C07D 241/36 (2006.01); C07D 401/00 (2006.01); C07D 215/16 (2006.01); C07D 405/00 (2006.01); C07D 409/00 (2006.01); C07D 411/00 (2006.01); C07D 413/00 (2006.01); C07D 417/00 (2006.01); C07D 419/00 (2006.01); C07D 421/00 (2006.01); C07C 211/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

Multifunctional compounds are provided, comprising two or more functional moieties selected from: (i) a moiety that imparts an iron chelator function; (ii) a moiety that imparts a neuroprotective function; (iii) a moiety that imparts combined antiapoptotic, neuroprotective and/or neurorestorative functions; (iv) a moiety that imparts brain MAO inhibition, preferably with little or no MAO inhibition in liver and small intestine; (v) a moiety that imparts cholinesterase inhibitory function; and (vi) a moiety that imparts an N-methyl-D-aspartic acid receptor (NMDAR) inhibition, and pharmaceutically acceptable salts and optical isomers thereof. The multifunctional compounds are useful in the treatment or prevention of diseases, disorders or conditions that can be prevented and/or treated by iron chelation therapy, and/or neuroprotection and/or neurorestoration, and/or apoptosis inhibition and/or MAO inhibition and/or cholinesterase inhibition and/or NMADR inhibition. The present invention encompasses compounds of the formulas I to VI.

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