The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2014
Filed:
Jun. 21, 2012
Garrit-jan Boudewijn Van Ommen, Amsterdam, NL;
Annemieke Aartsma-rus, Hoofddorp, NL;
Judith Christina Theodora Van Deutekom, Dordrecht, NL;
Josephus Johannes DE Kimpe, Utrecht, NL;
Joseph Stephan Verbeek, Leiden, NL;
Aliye Seda Ylmaz-elis, Hoofddorp, NL;
Garrit-Jan Boudewijn Van Ommen, Amsterdam, NL;
Annemieke Aartsma-Rus, Hoofddorp, NL;
Judith Christina Theodora Van Deutekom, Dordrecht, NL;
Josephus Johannes De Kimpe, Utrecht, NL;
Joseph Stephan Verbeek, Leiden, NL;
Aliye Seda Ylmaz-Elis, Hoofddorp, NL;
Prosensa Technologies B.V., Leiden, NL;
Academisch Ziekenhuis Leiden H.O.D.N. LUMC, Leiden, NL;
Abstract
The invention provides two types of oligonucleotides for treating an inflammatory disorder: an oligonucleotide which is able of altering the splicing of a pre-mRNA encoding a C5 in order to decrease the amount of a C5a and an oligonucleotide which is able of altering the splicing of a pre-mRNA encoding a IL-1RAcP in order to increase the amount of a soluble IL-1RAcP. The invention further provides the use of said oligonucleotides for preventing or treating an inflammatory disorder.