The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2014
Filed:
Aug. 14, 2009
Angelika Fretzen, Somerville, MA (US);
Steven Witowski, Melrose, MA (US);
Alfredo Grossi, Somerville, MA (US);
Hong Zhao, Lexington, MA (US);
Mahendra Dedhiya, Pomona, NY (US);
Yun MO, Commack, NY (US);
Angelika Fretzen, Somerville, MA (US);
Steven Witowski, Melrose, MA (US);
Alfredo Grossi, Somerville, MA (US);
Hong Zhao, Lexington, MA (US);
Mahendra Dedhiya, Pomona, NY (US);
Yun Mo, Commack, NY (US);
Ironwood Pharmaceuticals, Inc., Cambridge, MA (US);
Forest Laboratories Holdings, Ltd., Hamilton, BM;
Abstract
Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr ('linaclotide'; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.