The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2014
Filed:
Apr. 21, 2008
Abdessatar Sami Chtourou, Elancourt, FR;
Sébastien Lacroix-desmazes, Issy-les-Moulineaux, FR;
Srinivas Kaveri, Malakoff, FR;
Suryasarathi Dasgupta, Boston, MA (US);
Jagaadeesh Bayry, Issy-les-Moulineaux, FR;
Abdessatar Sami Chtourou, Elancourt, FR;
Sébastien Lacroix-Desmazes, Issy-les-Moulineaux, FR;
Srinivas Kaveri, Malakoff, FR;
Suryasarathi Dasgupta, Boston, MA (US);
Jagaadeesh Bayry, Issy-les-Moulineaux, FR;
Institut National de la Sante et de la Recherche Medicale (INSERM), Paris, FR;
LFB Biotechnologies, Les Ulis, FR;
Abstract
There is provided in accordance with the practice of this invention a demannosylated Factor VIII, the immunogenicity of which is substantially decreased or abolished in Human. The modified factor VIII is disclosed together with the modified amino acid sequence, changed by at least one substitution. The modified factor VIII is useful for hemophiliacs, either to avoid or prevent the action of inhibitory anti-FVIII antibodies.