The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2014
Filed:
Apr. 11, 2012
Jessie L.-s. AU, San Diego, CA (US);
M. Guillaume Wientjes, San Diego, CA (US);
Ze LU, Upper Arlington, OH (US);
Jie Wang, Columbus, OH (US);
Jessie L.-S. Au, San Diego, CA (US);
M. Guillaume Wientjes, San Diego, CA (US);
Ze Lu, Upper Arlington, OH (US);
Jie Wang, Columbus, OH (US);
Other;
Abstract
The present disclosure provides methods and compositions for enhanced delivery of siRNA or miRNA, into the interior of multilayered tissues, and into the cytoplasm or nucleus of cells of a tissue. Such methods and compositions yield tumor-selective and intracellular delivery of RNAi agents and allow for RNAi-mediated activity such as knock-down of the target genes and associated products. The current disclosure further provides methods and compositions for improving the intracellular bioavailability of nucleotide agents.