The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2014
Filed:
Aug. 07, 2009
Applicants:
Markus-rene Gold, Karlstadt, DE;
Herbert Koller, Vienna, AT;
Michael Pyerin, Brunn Am Gebirge, AT;
Inventors:
Assignee:
Merz Pharma GmbH & Co. KGaA, Frankfurt am Main, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 209/62 (2006.01); C07C 231/10 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention pertains to process for the amidation of a substituted 1-bromo-adamantane comprising a step (0) of reacting a substituted adamantane with an excess of bromine to obtain a 1-bromo-adamantane and a step (i) of reacting said substituted 1-bromo-adamantane with an amide, wherein the substituted 1-bromo-adamantane is used in the form of a mixture comprising bromine as obtained in step (0), wherein in step (0) a bromine: substituted adamantane molar ratio of from [2.5:1] to less than [5:1] is employed.