The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2014
Filed:
Nov. 08, 2012
Applicant:
Hoffmann-la Roche Inc., Nutley, NJ (US);
Inventors:
Bjoern Bartels, Schopfheim, DE;
Fritz Bliss, Hartheim, DE;
Philipp Cueni, Basel, CH;
Christophe Pfleger, Mulhouse, FR;
Ulrich Zutter, Basel, CH;
Assignee:
Hoffmann-La Roche Inc., Nutley, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 207/09 (2006.01);
U.S. Cl.
CPC ...
C07D 207/09 (2013.01);
Abstract
The present invention relates in part to a process for the preparation of a proline derivative of formula I wherein, The proline derivatives of the formula I are preferential inhibitors of the cysteine protease Cathepsin S and are therefore useful to treat metabolic diseases like diabetes, atherosclerosis, abdominal aortic aneurysm, peripheral arterial disease and diabetic nephropathy.