The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2014
Filed:
Feb. 22, 2013
James B. Delehanty, Washington, DC (US);
Igor L. Medintz, Washington, DC (US);
Hedi M. Mattoussi, Tallahassee, FL (US);
Jeffrey R. Deschamps, Laurel, MD (US);
Glyn Dawson, Chicago, IL (US);
Philip E. Dawson, San Diego, CA (US);
Juan Bautista Blanco-canosa, A Coruna, ES;
Kelly Boeneman, Arlington, VA (US);
James B. Delehanty, Washington, DC (US);
Igor L. Medintz, Washington, DC (US);
Hedi M. Mattoussi, Tallahassee, FL (US);
Jeffrey R. Deschamps, Laurel, MD (US);
Glyn Dawson, Chicago, IL (US);
Philip E. Dawson, San Diego, CA (US);
Juan Bautista Blanco-Canosa, A Coruna, ES;
Kelly Boeneman, Arlington, VA (US);
The United States of America, as represented by the Secretary of the Navy, Washington, DC (US);
The University of Chicago, Chicago, IL (US);
Abstract
Described are nucleic acids encoding a polypeptide for delivery of a nanoparticle to the cytosol, the peptide comprising: (a) a nanoparticle association domain, (b) a spacer domain, (c) an uptake domain, and (d) a vesicle escape domain, wherein the domains (a) through (d) appear in the same order as listed above, and wherein the peptide, upon addition of a non-hydrolyzable lipophilic moiety to the vesicle escape domain and binding to a nanoparticle, is effective to induce uptake of a nanoparticle by a cell and delivery of the nanoparticle to the cytosol of the cell. Also described are methods of delivery of a nanoparticle to the cytosol of a cell, the method comprising providing to a cell a nanoparticle attached to such a peptide. Exemplary nanoparticles include quantum dots.