The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 05, 2014

Filed:

Feb. 23, 2012
Applicants:

Rajan Anand, Fanwood, NJ (US);

James M. Apgar, Highland Park, NJ (US);

Tesfaye Biftu, Freehold, NJ (US);

Ping Chen, Edison, NJ (US);

Lin Chu, Scotch Plains, NJ (US);

Vincent J. Colandrea, North Brunswick, NJ (US);

Guizhen Dong, Dayton, NJ (US);

James F. Dropinski, Colts Neck, NJ (US);

Danqing Feng, Green Brook, NJ (US);

Jacqueline D. Hicks, Scotch Plains, NJ (US);

Jinlong Jiang, Scotch Plains, NJ (US);

Alexander J. Kim, Morganville, NJ (US);

Kenneth J. Leavitt, Plainsboro, NJ (US);

Bing LI, Towaco, NJ (US);

Xiaoxia Qian, New York, NY (US);

Iyassu Sebhat, Jersey City, NJ (US);

Lan Wei, Berkeley Heights, NJ (US);

Robert R. Wilkening, Maplewood, NJ (US);

Zhicai Wu, Montvale, NJ (US);

Inventors:

Rajan Anand, Fanwood, NJ (US);

James M. Apgar, Highland Park, NJ (US);

Tesfaye Biftu, Freehold, NJ (US);

Ping Chen, Edison, NJ (US);

Lin Chu, Scotch Plains, NJ (US);

Vincent J. Colandrea, North Brunswick, NJ (US);

Guizhen Dong, Dayton, NJ (US);

James F. Dropinski, Colts Neck, NJ (US);

Danqing Feng, Green Brook, NJ (US);

Jacqueline D. Hicks, Scotch Plains, NJ (US);

Jinlong Jiang, Scotch Plains, NJ (US);

Alexander J. Kim, Morganville, NJ (US);

Kenneth J. Leavitt, Plainsboro, NJ (US);

Bing Li, Towaco, NJ (US);

Xiaoxia Qian, New York, NY (US);

Iyassu Sebhat, Jersey City, NJ (US);

Lan Wei, Berkeley Heights, NJ (US);

Robert R. Wilkening, Maplewood, NJ (US);

Zhicai Wu, Montvale, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/00 (2006.01); C07D 513/02 (2006.01);
U.S. Cl.
CPC ...
Abstract

Novel compounds of structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.


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