The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2014
Filed:
Jul. 18, 2007
Joanna Kubler-kielb, Bethesda, MD (US);
Vince Pozsgay, Washington, DC (US);
Teresa Lagergard, Kullavik, SE;
Gil Ben-menachem, Newton, MA (US);
Rachel Schneerson, Bethesda, MD (US);
Evguenii Vinogradov, Ottawa, CA;
Ariel Ginzberg, Rockville, MD (US);
Joanna Kubler-Kielb, Bethesda, MD (US);
Vince Pozsgay, Washington, DC (US);
Teresa Lagergard, Kullavik, SE;
Gil Ben-Menachem, Newton, MA (US);
Rachel Schneerson, Bethesda, MD (US);
Evguenii Vinogradov, Ottawa, CA;
Ariel Ginzberg, Rockville, MD (US);
The United States of America, as represented by the Secretary, Department of Health and Human Services, Washington, DC (US);
National Research Council of Canada, Ottawa, CA;
Abstract
Methods for preparing an oligosaccharide-protein carrier immunogenic conjugate or a polysaccharide-protein carrier immunogenic conjugate. The methods include obtaining an oligosaccharide or polysaccharide having a KDO moiety located at the terminal reducing end of the oligosaccharide or polysaccharide that includes a carbonyl functional group; and reacting the carbonyl functional group of the KDO moiety with an aminooxylated protein carrier molecule resulting in a conjugate that includes a covalent oxime bond between the oligosaccharide and the protein carrier or the polysaccharide and the protein carrier.