The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2014
Filed:
Oct. 25, 2007
Applicants:
Arthur Brown, London, CA;
Paul Gris, Chapel Hill, NC (US);
Inventors:
Arthur Brown, London, CA;
Paul Gris, Chapel Hill, NC (US);
Assignee:
Robarts Research Institute, London, Ontario, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
A method of treating a pathophysiological condition caused by the production of growth-inhibiting proteoglycans is provided. It is based on the finding that down-regulation of SOX9 results in decreased production of growth-inhibiting factors such as proteoglycans, and increased production of growth-promoting factors such as a laminin and fibronectin. The method of the present invention comprises the inhibition of SOX9 expression and function with an inhibitor such as an antisense oligonucleotide or a siRNA.