The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8791083 B1

PDF
Full Text
Expired
Date of Patent:
Jul. 29, 2014

Filed:

Feb. 19, 2009
Applicants:

Brett P. Monia, Encinitas, CA (US);

Madeline M. Butler, Rancho Santa Fe, CA (US);

Robert Mckay, Oceanside, CA (US);

Brenda F. Baker, Carlsbad, CA (US);

Inventors:

Brett P. Monia, Encinitas, CA (US);

Madeline M. Butler, Rancho Santa Fe, CA (US);

Robert McKay, Oceanside, CA (US);

Brenda F. Baker, Carlsbad, CA (US);

Assignee:

Isis Pharmaceuticals, Inc., Carlsbad, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to novel chimeric oligomeric compounds having a plurality of alternating regions having either RNA like having northern or 3'-endo conformational geometry (3′-endo regions) or DNA like having southern or C2′-endo/O4′-endo conformational geometry. The oligomeric compounds of the present invention have shown reduction in mRNA levels in multiple in vitro and in vivo assay systems and are useful, for example, for investigative and therapeutic purposes.


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Monia, Brett. (2014). Chimeric oligomeric compounds comprising alternating regions of northern and southern conformational geometry (U.S. Patent No. 8791083). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8791083

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