The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2014
Filed:
Feb. 19, 2009
Brett P. Monia, Encinitas, CA (US);
Madeline M. Butler, Rancho Santa Fe, CA (US);
Robert Mckay, Oceanside, CA (US);
Brenda F. Baker, Carlsbad, CA (US);
Brett P. Monia, Encinitas, CA (US);
Madeline M. Butler, Rancho Santa Fe, CA (US);
Robert McKay, Oceanside, CA (US);
Brenda F. Baker, Carlsbad, CA (US);
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Abstract
The present invention relates to novel chimeric oligomeric compounds having a plurality of alternating regions having either RNA like having northern or 3'-endo conformational geometry (3′-endo regions) or DNA like having southern or C2′-endo/O4′-endo conformational geometry. The oligomeric compounds of the present invention have shown reduction in mRNA levels in multiple in vitro and in vivo assay systems and are useful, for example, for investigative and therapeutic purposes.