The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2014
Filed:
Nov. 14, 2011
Bruce A. Sullenger, Durham, NC (US);
Shahid Nimjee, Durham, NC (US);
Sabah Oney, Palo Alto, CA (US);
Nanette Que-gewirth, Durham, NC (US);
Bruce A. Sullenger, Durham, NC (US);
Shahid Nimjee, Durham, NC (US);
Sabah Oney, Palo Alto, CA (US);
Nanette Que-Gewirth, Durham, NC (US);
Duke University, Durham, NC (US);
Abstract
The present invention relates, in general, to receptors and to platelet aggregation and, in particular, to a method of inhibiting platelet aggregation using an aptamer that binds to and inhibits the activity of a receptor, such as glycoprotein IIb/IIIa (gpIIb/IIIa), and to aptamers suitable for use in such a method. The invention also relates to antidotes to antiplatelet agents and to methods of using such antidotes to reverse aptamer-induced platelet inhibition. The invention further relates to von Willebrand Factor (VWF) inhibitors, and antidotes therefore, and to methods of using same.