The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2014
Filed:
May. 26, 2009
Pieter Cullis, Vancouver, CA;
Marcel Bally, Bowen Island, CA;
Marco Ciufolini, Vancouver, CA;
Norbert Maurer, Vancouver, CA;
Igor Jigaltsev, Vancouver, CA;
Pieter Cullis, Vancouver, CA;
Marcel Bally, Bowen Island, CA;
Marco Ciufolini, Vancouver, CA;
Norbert Maurer, Vancouver, CA;
Igor Jigaltsev, Vancouver, CA;
The University of British Columbia, Vancouver, CA;
Abstract
Drag derivatives are provided herein which are suitable for loading into liposomal nanoparticle carriers. In some preferred aspects, the derivatives comprise a poorly water-soluble drag derivatized with a weak-base moiety that facilitates active loading of the drag through a LN transmembrane pH or ion gradient into the aqueous interior of the LN. The weak-base moiety can optionally comprise a lipophilic domain that facilitates active loading of the drag to the inner monolayer of the liposomal membrane. Advantageously, LN formulations of the drag derivatives exhibit improved solubility, reduced toxicity, enhanced efficacy, and/or other benefits relative to the corresponding free drags.