The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2014
Filed:
Apr. 04, 2011
Peter Kufer, Moosburg, DE;
Meera Berry, Ulm, DE;
Sonja Offner, Munich, DE;
Klaus Brischwein, Munich, DE;
Andreas Wolf, Planegg, DE;
Tobias Raum, Munich, DE;
Birgit Kohleisen, Munich, DE;
Ulla Lenkkeri-schütz, Eching, DE;
Patrick Bauerle, Gauting, DE;
Peter Kufer, Moosburg, DE;
Meera Berry, Ulm, DE;
Sonja Offner, Munich, DE;
Klaus Brischwein, Munich, DE;
Andreas Wolf, Planegg, DE;
Tobias Raum, Munich, DE;
Birgit Kohleisen, Munich, DE;
Ulla Lenkkeri-Schütz, Eching, DE;
Patrick Bauerle, Gauting, DE;
Amgen Research (Munich) GmbH, Munich, DE;
Abstract
The present invention provides a pharmaceutical composition comprising a bispecific single chain antibody construct. Said bispecific single chain antibody construct is characterized to comprise or consist of at least two domains, whereby one of said at least two domains specifically binds to human EpCAM and comprises at least one CDR-H3 region comprising the amino acid sequence NXID antigen and a second domain binds to human CD3 antigen. The invention further provides a process for the production of the pharmaceutical composition of the invention, a method for the prevention, treatment or amelioration of a tumorous disease and the use of the disclosed bispecific single chain antibody construct and corresponding means in the prevention, treatment or amelioration of a tumorous disease.