The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2014
Filed:
Mar. 24, 2009
Takashi Miki, Toyonaka, JP;
Yasuharu Shimasaki, Toyonaka, JP;
Srinivasan Babu, South San Francisco, CA (US);
Zhigang Cheng, South San Francisco, CA (US);
Mark E. Reynolds, South San Francisco, CA (US);
Qingping Tian, South San Francisco, CA (US);
Takashi Miki, Toyonaka, JP;
Yasuharu Shimasaki, Toyonaka, JP;
Srinivasan Babu, South San Francisco, CA (US);
Zhigang Cheng, South San Francisco, CA (US);
Mark E. Reynolds, South San Francisco, CA (US);
Qingping Tian, South San Francisco, CA (US);
Sumitomo Chemical Company, Limited, Tokyo, JP;
Genentech, Inc., South San Francisco, CA (US);
Abstract
The present invention relates to a method for manufacturing a boronic acid ester compound, characterized by reacting an aryl halide compound and a diboron ester compound in the presence of a nitrogen-containing organic base, a nickel catalyst, a phosphine compound and a solvent. According to the manufacturing method of the present invention, even if a nickel catalyst is used as the catalyst, a desired boronic acid ester compound can be obtained in a sufficiently high yield. Furthermore, even if aryl chloride or aryl bromide having relatively low price and low reactivity, was used as the aryl halide compound, a desired boronic acid ester compound can be obtained in a sufficiently high yield.