The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2014
Filed:
Oct. 22, 2010
Samuel S. Nam, Haverhill, MA (US);
Edward A. Greenfield, Stoughton, MA (US);
Theresa L. O'keefe, Waltham, MA (US);
Shixin Qin, Lexington, MA (US);
John Babcook, Vancouver, CA;
Samuel S. Nam, Haverhill, MA (US);
Edward A. Greenfield, Stoughton, MA (US);
Theresa L. O'Keefe, Waltham, MA (US);
Shixin Qin, Lexington, MA (US);
John Babcook, Vancouver, CA;
Millennium Pharmaceuticals, Inc., Cambridge, MA (US);
Amgen British Columbia, Burnaby, BC, CA;
Abstract
Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. The antibodies bind an extracellular domain of GCC and can be internalized. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.