The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2014
Filed:
Oct. 12, 2010
Applicants:
Paula A. Witt-enderby, Bethel Park, PA (US);
Vicki L. Davis, Seven Fields, PA (US);
David Lapinsky, Allison Park, PA (US);
Inventors:
Paula A. Witt-Enderby, Bethel Park, PA (US);
Vicki L. Davis, Seven Fields, PA (US);
David Lapinsky, Allison Park, PA (US);
Assignee:
Duquesne University of the Holy Spirit, Pittsburgh, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 33/02 (2006.01); A61K 31/135 (2006.01); A01N 43/38 (2006.01); A61K 31/405 (2006.01);
U.S. Cl.
CPC ...
Abstract
A particularly constructed tamoxifen-melatonin hybrid ligand gives new and unexpectedly improved results in the prevention and treatment of cancer, particularly breast cancer. The hybrid ligand comprises either tamoxifen or 4-hydroxytamoxifen and also melatonin, with the tamoxifen or 4-hydroxytamoxifen and melatonin's being linked by an unsubstituted C-Calkyl linker between the tamoxifen amine and the carbonyl of melatonin.