IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8785489 B1

PDFFull Text
Date of Patent:
Jul. 22, 2014

Filed:

Oct. 13, 2009

Heteroaryl substituted indole compounds useful as mmp-13 inhibitors

Applicants:

Asitha Abeywardane, Danbury, CT (US);

Bennett Farmer, Ridgefield, CT (US);

Neil Alexander Farrow, Ridgefield, CT (US);

Donghong Amy Gao, Hopewell Junction, NY (US);

Alexander Heim-riether, Biberach an der Riss, DE;

Lana Louise Smith Keenan, Poughquag, NY (US);

Ingo Andreas Mugge, New Haven, CT (US);

Steven John Taylor, Southbury, CT (US);

Zhaoming Xiong, Brookfield, CT (US);

Yang Yu, Clark, NJ (US);

Qiang Zhang, Woodbury, CT (US);

Inventors:

Asitha Abeywardane, Danbury, CT (US);

Bennett Farmer, Ridgefield, CT (US);

Neil Alexander Farrow, Ridgefield, CT (US);

Donghong Amy Gao, Hopewell Junction, NY (US);

Alexander Heim-Riether, Biberach an der Riss, DE;

Lana Louise Smith Keenan, Poughquag, NY (US);

Ingo Andreas Mugge, New Haven, CT (US);

Steven John Taylor, Southbury, CT (US);

Zhaoming Xiong, Brookfield, CT (US);

Yang Yu, Clark, NJ (US);

Qiang Zhang, Woodbury, CT (US);

Assignee:

Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;

Attorneys:

Michael P. Morris

Anthony P. Bottino

Primary Examiner:

Joseph Kosack

Assistant Examiner:

Matthew Coughlin

Int. Cl.
CPC ...
A61K 31/5377 (2006.01); A61K 31/506 (2006.01); A61K 31/497 (2006.01); A61K 31/454 (2006.01); A61K 31/444 (2006.01); A61K 31/4439 (2006.01); A61K 31/427 (2006.01); A61K 31/422 (2006.01); A61K 31/4178 (2006.01); A61K 31/4155 (2006.01); A61K 31/404 (2006.01); C07D 413/14 (2006.01); C07D 413/04 (2006.01); C07D 409/14 (2006.01); C07D 409/04 (2006.01); C07D 405/14 (2006.01); C07D 405/04 (2006.01); C07D 403/14 (2006.01); C07D 403/04 (2006.01); C07D 401/14 (2006.01); C07D 401/04 (2006.01); C07D 487/04 (2006.01); C07D 405/12 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 209/42 (2006.01);
U.S. Cl.
CPC ...
A61K 31/427 (2013.01); A61K 31/4155 (2013.01); C07D 401/04 (2013.01); C07D 409/14 (2013.01); A61K 31/454 (2013.01); A61K 31/422 (2013.01); C07D 405/14 (2013.01); C07D 405/04 (2013.01); C07D 403/14 (2013.01); C07D 487/04 (2013.01); A61K 31/4439 (2013.01); C07D 405/12 (2013.01); A61K 31/497 (2013.01); C07D 409/04 (2013.01); C07D 417/14 (2013.01); C07D 413/14 (2013.01); C07D 401/14 (2013.01); A61K 31/404 (2013.01); C07D 471/04 (2013.01); C07D 209/42 (2013.01); C07D 403/04 (2013.01); A61K 31/444 (2013.01); C07D 413/04 (2013.01); A61K 31/506 (2013.01); A61K 31/4178 (2013.01); A61K 31/5377 (2013.01);
Abstract

Disclosed are compounds and compositions of the formula I as described herein which are inhibitors of MMP-13. Also disclosed are methods of using and making compounds of the formula I.

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