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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8785178 B1

PDFFull Text
Date of Patent:
Jul. 22, 2014

Filed:

Jan. 12, 2007

Perifusion device

Applicants:

Ramon E. Poo, Miami, FL (US);

Camillo Ricordi, Miami, FL (US);

Felipe Echeverri, Miami, FL (US);

Over Cabrera, Deerfield Beach, FL (US);

Per-olof Berggren, Miami, FL (US);

Inventors:

Ramon E. Poo, Miami, FL (US);

Camillo Ricordi, Miami, FL (US);

Felipe Echeverri, Miami, FL (US);

Over Cabrera, Deerfield Beach, FL (US);

Per-Olof Berggren, Miami, FL (US);

Assignees:

Biorep Technologies, Inc., Miami, FL (US);

University of Miami, Miami, FL (US);

Attorney:

Novak Druce Connolly Bove + Quigg LLP

Primary Examiner:

William H Beisner

Int. Cl.
CPC ...
C12M 3/00 (2006.01); C12M 1/16 (2006.01); C12M 1/34 (2006.01); C12M 1/32 (2006.01); C12M 1/00 (2006.01); C12M 1/42 (2006.01); C12M 1/26 (2006.01);
U.S. Cl.
CPC ...
C12M 41/36 (2013.01); C12M 23/12 (2013.01); C12M 41/14 (2013.01); C12M 41/00 (2013.01); C12M 41/46 (2013.01); C12M 29/10 (2013.01); C12M 35/04 (2013.01); C12M 33/10 (2013.01);
Abstract

A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A computer can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles. The test liquid includes at least one stimuli for the cells, which can be the presence, absence, or concentration of a compound in the liquid, or a physical property of the liquid such as temperature. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.

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