The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 2014
Filed:
Jan. 25, 2008
Applicants:
Jun Tan, Tampa, FL (US);
Doug Shytle, Lutz, FL (US);
Kavon Rezai-zadeh, Tampa, FL (US);
Inventors:
Assignee:
University of South Florida, Tampa, FL (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 311/30 (2006.01); A61K 31/352 (2006.01);
U.S. Cl.
CPC ...
C07D 311/30 (2013.01); A61K 31/352 (2013.01);
Abstract
The bioflavonoid luteolin reduces amyloid-β peptide (Aβ) generation. Luteolin is also a selective GSK-3 inhibitor that 1) decreases amyloidogenic γ-secretase APP processing, and 2) promotes presenilin-1 (PS1) carboxyl-terminal fragment (CTF) phosphorylation. GSK-3α activity is essential for both PS1 CTF phosphorylation states and PS1-APP interaction. To validate The findings were validated in vivo, using a Tg2576 Alzheimer's Disease model system. Luteolin treatment decreased soluble Aβ levels, reduced GSK-3 activity, and disrupted PS1-APP association.