The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 15, 2014

Filed:

Aug. 04, 2010
Applicants:

Tomohiro Toyoda, Suita, JP;

Tomoaki Nishida, Osaka, JP;

Hidefumi Yoshinaga, Osaka, JP;

Inventors:

Tomohiro Toyoda, Suita, JP;

Tomoaki Nishida, Osaka, JP;

Hidefumi Yoshinaga, Osaka, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/453 (2006.01); C07D 405/10 (2006.01);
U.S. Cl.
CPC ...
Abstract

Provided is a new serotonin-reuptake inhibitor that exhibits affinity for serotonin-1A receptors. Said serotonin-reuptake inhibitor is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. In the formula, Rrepresents a hydrogen atom, a 2-hydroxyethyl group, or a 2-methoxyethyl group. Rrepresents one of the following bonded to a methylene group which is bonded to a piperidine ring: a chlorine atom bonded in a p-position; a bromine atom bonded in a p-position; a methyl group bonded in a p-position; a chlorine atom bonded in an m-position; or a bromine atom bonded in an m-position. Either Yrepresents a hydrogen atom and Yrepresents a hydrogen atom or a hydroxyl group, or Yand Ytogether represent an oxo group. Z represents a group represented by one of the following formulas: formula (3-1-1), formula (3-1-2), formula (3-2-1), formula (3-2-2), formula (3-3-1), formula (3-3-2), formula (3-4-1), or formula (3-4-2). However, if Rrepresents a 2-hydroxyethyl group or a 2-methoxyethyl group and Yand Yboth simultaneously represent hydrogen atoms, then Z represents a group represented by one of the following formulas: formula (3-1-2), formula (3-2-1), formula (3-2-2), formula (3-3-1), formula (3-3-2), formula (3-4-1), or formula (3-4-2).


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