The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 2014
Filed:
Sep. 28, 2009
Marion Dorsch, Jamaica Plain, MA (US);
John E. Monahan, Walpole, MA (US);
Michael Patrick Morrissey, Watertown, MA (US);
Shifeng Pan, San Diego, CA (US);
Juliet Williams, London, GB;
Marion Dorsch, Jamaica Plain, MA (US);
John E. Monahan, Walpole, MA (US);
Michael Patrick Morrissey, Watertown, MA (US);
Shifeng Pan, San Diego, CA (US);
Juliet Williams, London, GB;
Novartis AG, Basel, CH;
Abstract
The invention provides methods for modulating, e.g., antagonizing, the activity of the Hedgehog signaling pathway, and for treating Hedgehog related disorders such as cancers (e.g., medulloblastoma). In particular, the invention provides methods for inhibiting aberrant growth states resulting from phenotypes such as Ptch loss-of-function, Hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function by administering to a mammal combinations of Smoothened inhibitors (e.g., a compound of Formula I, Formula II, or Formula III, or any of the compounds listed herein or incorporated by reference) and cholesterol biosynthesis pathway inhibitors (e.g., statins), Gli inhibitors, and/or Phosphatidylinositol 3-kinase (PI3K) inhibitors.