The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 15, 2014

Filed:

Dec. 12, 2012
Applicant:

Receptos, Inc., San Diego, CA (US);

Inventors:

Marcus F. Boehm, San Diego, CA (US);

Esther Martinborough, San Diego, CA (US);

Manisha Moorjani, San Diego, CA (US);

Junko Tamiya, Carlsbad, CA (US);

Liming Huang, San Diego, CA (US);

Adam R. Yeager, La Mesa, CA (US);

Enugurthi Brahmachary, San Diego, CA (US);

Thomas Fowler, Melton Mowbray, GB;

Andrew Novak, Nottingham, GB;

Premji Meghani, Leicestershire, GB;

Michael Knaggs, Burton-on-Trent, GB;

Assignee:

Receptos, Inc., San Diego, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/33 (2006.01); C07D 291/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/33 (2013.01); C07D 291/00 (2013.01);
Abstract

The invention relates to compounds that modulate the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds are act as modulators or potentiators of GLP-1 receptor on their own, or with receptor ligands including GLP-1 peptides GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where '' represents either or both the R and S form of the compound): where A, B, C, Y, Y, Z, R, R, R, R, R, W, n, p and q are as defined herein.


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