The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 2014
Filed:
Jun. 26, 2006
Frederik Jan Rita Rombouts, Antwerp, BE;
Christopher John Love, Deurne, BE;
Kristof Van Emelen, Sint-Niklaas, BE;
Sven Franciscus Anna Van Brandt, Nijlen, BE;
Tongfei Wu, Turnhout, BE;
Frederik Jan Rita Rombouts, Antwerp, BE;
Christopher John Love, Deurne, BE;
Kristof Van Emelen, Sint-Niklaas, BE;
Sven Franciscus Anna Van Brandt, Nijlen, BE;
Tongfei Wu, Turnhout, BE;
Janssen Pharmaceutica NV, Beerse, BE;
Abstract
The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein m represents 1, n represents 1, Z represents N or C, in particular N; —X— represents Calkyl, in particular methyl; —X— represents —Calkyl- or —Calkyl-NR—, in particular propyl, -ethyl-NR— or -propyl-NR—; —Y— represents —NR—Calkyl-CO—NR—, -Het-Calkyl-CO—NR— or -Het-CO—NR— and wherein the —Calkyl-linker of —NR—Calkyl-CO—NR— or -Het-Calkyl-CO—NR— is optionally substituted with one or where possible two or more substituents selected from hydroxy, halo and phenyl; Rrepresents hydrogen, chloro, fluoro or bromo; Rrepresents —Calkyl-, in particular ethyl or methyl; Rrepresents hydrogen; Rrepresents hydrogen; R, Rand Rrepresent hydrogen; Hetis selected from piperazinyl or piperidinyl, in particular -piperazinyl; Hetselected from pyrrolidinyl or piperidinyl, in particular pyrrolidinyl wherein said pyrrolidinyl is optionally substituted with hydroxy.