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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8778886 B1

PDFFull Text
Date of Patent:
Jul. 15, 2014

Filed:

Feb. 26, 2010

Methods of making and using a cell penetrating peptide for enhanced delivery of nucleic acids, proteins, drugs, and adenovirus to tissues and cells, and compositions and kits

Applicants:

Rajendra Kumar-singh, Boston, MA (US);

Siobhan M. Cashman, Boston, MA (US);

Sarah Parker Read, Cambridge, MA (US);

Inventors:

Rajendra Kumar-Singh, Boston, MA (US);

Siobhan M. Cashman, Boston, MA (US);

Sarah Parker Read, Cambridge, MA (US);

Assignee:

Tufts University, Boston, MA (US);

Attorneys:

Lawson & Weitzen LLP

Sonia K. Guterman

Preeti T. Arun

Primary Examiner:

James H Alstrum Acevedo

Assistant Examiner:

Thea D' Ambrosio

Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 47/00 (2006.01); A61K 38/16 (2006.01); A61K 38/10 (2006.01); A61K 38/08 (2006.01); A61K 39/385 (2006.01); A61K 38/04 (2006.01); A61M 31/00 (2006.01); A61P 9/10 (2006.01); A61P 27/02 (2006.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

A peptide-POD with ability to penetrate and deliver fluorophores, siRNA, DNA and quantum dots to cells in culture and retinal and ocular tissues in vivo is provided herein. POD couples to adenovirus vectors, enhancing tropism for certain cells, potentially providing a safer and more efficacious method to deliver molecules to ocular and other tissues in vivo. POD constructs are therapeutic delivery vehicles for treating cells and tissues, including ocular cells and tissues suffering from retinal degeneration.

Find Patent Forward Citations

Kumar-Singh, Rajendra. (2014). Methods of making and using a cell penetrating peptide for enhanced delivery of nucleic acids, proteins, drugs, and adenovirus to tissues and cells, and compositions and kits (U.S. Patent No. 8778886). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8778886

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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