The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 2014
Filed:
Jan. 12, 2010
Alexei M. Voloshin, South San Francisco, CA (US);
James F. Zawada, South San Francisco, CA (US);
Daniel Gold, South San Francisco, CA (US);
Christopher James Murray, Soquel, CA (US);
James Edward Rozzelle, San Francisco, CA (US);
Nathan Uter, South San Francisco, CA (US);
Gang Yin, South San Francisco, CA (US);
Alexei M. Voloshin, South San Francisco, CA (US);
James F. Zawada, South San Francisco, CA (US);
Daniel Gold, South San Francisco, CA (US);
Christopher James Murray, Soquel, CA (US);
James Edward Rozzelle, San Francisco, CA (US);
Nathan Uter, South San Francisco, CA (US);
Gang Yin, South San Francisco, CA (US);
Sutro Biopharma, Inc., South San Francisco, CA (US);
Abstract
This invention provides for a novel means of incorporating non-native amino acids into preselected positions of a protein using a cell-free synthesis system. The methods involve the use of non-orthogonal, native isoaccepting sense tRNAs that are encoded by the genetic code. Such methods allow for numerous non-native amino acids to be incorporated through the use of sense codons without having to rely upon orthogonal tRNA-synthetase pairs.