The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 08, 2014
Filed:
Dec. 10, 2009
Applicants:
Vaheh Oganesyan, North Potomac, MD (US);
William F. Dall'acqua, Gaithersburg, MD (US);
Herren Wu, Boyds, MD (US);
Inventors:
Vaheh Oganesyan, North Potomac, MD (US);
William F. Dall'Acqua, Gaithersburg, MD (US);
Herren Wu, Boyds, MD (US);
Assignee:
MedImmune, LLC, Gaithersburg, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01V 1/40 (2006.01); C12P 21/08 (2006.01); G01N 31/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
Provided herein are crystalline forms of a human IgG Fc variant comprising triple-mutation M252Y/S254T/T256E that provides for increased binding affinity to human neonatal Fc receptor, methods of obtaining such crystals and high-resolution X-ray diffraction structures and atomic structure coordinates. Also provided are machine readable media embedded with the three-dimensional atomic structure coordinates of the human IgG Fc variant and methods of using them.