The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 08, 2014
Filed:
May. 21, 2008
Applicants:
Joseph Thomas, Raleigh, NC (US);
Michael T. Cash, Timberlake, NC (US);
Inventors:
Joseph Thomas, Raleigh, NC (US);
Michael T. Cash, Timberlake, NC (US);
Assignee:
Becton, Dickinson and Company, Franklin Lakes, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/533 (2006.01); G01N 33/53 (2006.01); C12M 1/34 (2006.01); G01N 33/58 (2006.01); A61K 8/49 (2006.01);
U.S. Cl.
CPC ...
G01N 33/582 (2013.01); A61K 8/498 (2013.01); C12M 1/34 (2013.01); G01N 33/53 (2013.01);
Abstract
The presently disclosed subject matter provides thiol-reactive, environmentally sensitive fluorescent dyes, or fluorophores, which have an emission wavelength in the visible spectral region. When conjugated with a binding protein, the fluorophores exhibit a ratiometric response to one or more ligands or target analytes. The presently disclosed fluorophore-binding protein conjugates can be used to detect the presence of or amount of physiologically-important metabolites, such as glucose, fatty acids, and lactate, in biological samples.