The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 08, 2014
Filed:
Oct. 12, 2011
Yasuaki Takakura, Kawasaki, JP;
Hiroomi Ogino, Kawasaki, JP;
Masakazu Sugiyama, Kawasaki, JP;
Kenichi Mori, Kawasaki, JP;
Eri Tabuchi, Kawasaki, JP;
Koki Ishikawa, Kawasaki, JP;
Uno Tagami, Kawasaki, JP;
Hidemi Fujii, Kawasaki, JP;
Yasuaki Takakura, Kawasaki, JP;
Hiroomi Ogino, Kawasaki, JP;
Masakazu Sugiyama, Kawasaki, JP;
Kenichi Mori, Kawasaki, JP;
Eri Tabuchi, Kawasaki, JP;
Koki Ishikawa, Kawasaki, JP;
Uno Tagami, Kawasaki, JP;
Hidemi Fujii, Kawasaki, JP;
Ajinomoto Co., Inc., Tokyo, JP;
Abstract
The present invention provides a methodology for improving a yield of 2R,4R-Monatin. Specifically, the present invention provides a method for producing 2S,4R-Monatin or a salt thereof, comprising contacting 4R-IHOG with an L-amino acid aminotransferase in the presence of an L-amino acid to form the 2S,4R-Monatin; a method for producing 2R,4R-Monatin or a salt thereof, comprising isomerizing the 2S,4R-Monatin to form the 2R,4R-Monatin; and the like. These production methods may further comprise condensing indole-3-pyruvate and pyruvate to form the 4R-IHOG, and deaminating a tryptophan to form the indole-3-pyruvate.