The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 08, 2014
Filed:
Jan. 13, 2011
Applicants:
Ridong Chen, Naperville, IL (US);
Soon Seog Jeong, Naperville, IL (US);
Inventors:
Ridong Chen, Naperville, IL (US);
Soon Seog Jeong, Naperville, IL (US);
Assignee:
APT Therapeutics, Inc., St. Louis, MO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/46 (2006.01);
U.S. Cl.
CPC ...
Abstract
This invention provides a new class of enhanced apyrases (EN-apyrases) with superior pharmacokinetic, pharmacodynamic, and pharmacochemical properties and which can be purified using simplified procedures. The invention further provides constructs for transforming a cell to produce these EN-apyrases. The EN-apyrase construct comprises sequences encoding a signal sequence, a linker, and a soluble apyrase. Also provided are preparations of apyrases and methods for producing apyrase in culture cells and purification thereof.